Rewiring the System

Every Moment An Environment

Every Moment is packed with meaning. I have been talking or typing all about the emotions involved with my breast cancer. I have met and learned so much about this from the fact that I kept talking about it here and in places in my three diminutional life.

On one list, a spiritual practice list, I got a communication that I needed to grow up. On another list I belong to people told me that I was an inspiration. I am Johanna Van Doe in the headlights right now.

It turns out that having a problem is a learning experience.

It is like discovering stuff. Suddenly doing research and talking about it is the makings of a rock star in this the information age. Where do we turn now that the TED is every day information WOW!?

Back at the beginning on this process of information gathering is Cancer, Breast Cancer. The general pervasive unbalance that one out of five woman in the world is currently living with and through. My Breast Cancer. The dreaded first conversation after the mammogram is something everyone who has been told they have cancer understands.

My appointment at the clinical trials the doctors treated me like a dumb cow and used code words to describe my cancer. It was a real wake up call about information corralling by those who have it. It is a control issue that is built on a belief that people are not smart or capable enough to make cogent choices about their own lives. Yea! That Conversation IS Over ….

I am told in medical code that my cancer is Environmental. Tell me what the environment is? Moving Forward is a tug of war between those filled with fear of life as a dieing game and those living in fear of losing power over the powerless. Information age is for the informed.

I have spent months going to lectures on each piece of the minutiae which bricks up the wall keeping the patient on the outside of the long information process.

Stress, Inflammation, Improper Diet, Lack Of Exercise, Low Self Esteem,  Lock Step Reactions to the Junk Life Deals Everyone!  Bad Friends, Difficult Family, Lack Of Community Care, Religious Connections That Only Want You For Your Money.

Today I went to LBL for a talk about the chemistry of the sympathetic and the para sympathetic systems on creating thickening or thinning of the heart muscle. It is the change that happen when fat lipids swimming around in the blood stream get flipped into glycol during adrenal overload. This is what Environmental Conditions means in the creation of disease and aging. I hear at Stanford at several talks I attend over more than a few months about community and rewards, and  then proper feeding  health.

There is hard science in the communication, replication and demise of genes. It is this hard science that fuels the wake up call in the difficult process of choosing life sufficiently to actually change your bad choices and proclivities into what is good for the castle which you carry around to give your spark a home.

The Mother of all Cancer is:

Plaque In all its forms are a sentinal of cancer, heart failure and diabetes.

The name amyloid comes from the early mistaken identification of the substance as starch (amylum in Latin), based on crude iodine-staining techniques. For a period, the scientific community debated whether or not amyloid deposits were fatty deposits or carbohydrate deposits until it was finally found that they were, in fact, deposits of proteinaceous mass.

To my way of thinking about Cancer starts here in this

There are two broad classes of amyloid-forming polypeptide sequences. Glutamine-rich polypeptides are important in the amyloidogenesis of Yeast and mammalian prions, as well asTrinucleotide repeat disorders including Huntington’s disease. When peptides are in a beta-sheet conformation, particularly when the residues are parallel and in-register (causing alignment), glutamines can brace the structure by forming intrastrand hydrogen bonding between its amide carbonyls and nitrogens. In general, for this class of diseases, toxicity correlates with glutamine content.This has been observed in studies of onset age for Huntington’s disease (the longer the polyglutamine sequence, the sooner the symptoms appear), and has been confirmed in a C. elegans model system with engineered polyglutamine peptides

Other polypeptides and proteins such as amylin and the Alzheimer’s beta protein do not have a simple consensus sequence and are thought to operate by hydrophobic association.[citation needed]Among the hydrophobic residues, aromatic amino-acids are found to have the highest amyloidogenic propensity

For these peptides, cross-polymerization (fibrils of one polypeptide sequence causing other fibrils of another sequence to form) is observed in vitro and possibly in vivo.This phenome non is important since it would explain interspecies prion propagation and differential rates of prion propagation, as well as a statistical link between Alzheimer’s and type 2 diabetes. In general, the more similar the peptide sequence the more efficient cross-polymerization is, though entirely dissimilar sequences can cross-polymerize and highly similar sequences can even be “blockers” which prevent polymerization. Polypeptides will not cross-polymerize their mirror-image counterparts, indicating that the phenomenon involves specific binding and recognition events.

Amyloid pathology

The reasons for amyloid association with disease is unclear. In some cases, the deposits physically disrupt tissue architecture, suggesting disruption of function by some bulk process. An emerging consensus implicates prefibrillar intermediates, rather than mature amyloid fibers, in causing cell death

Studies have shown that amyloid deposition is associated with mitochondrial dysfunction and a resulting generation of reactive oxygen species (ROS), which can initiate a signaling pathway leading to apoptosis.

These proteins are typically characterized by their ability to cause aggregation of healthy protein.

Atheromatous plaque, a buildup of white blood cell (sometimes termed fatty, despite absence of adipocytes) deposits within the wall of an artery

Senile plaques, an extracellular protein buildup implicated in various diseases such as Alzheimer’s disease and Parkinson’s disease

Mucoid plaque, a supposed thick coating of abnormal mucous material in the colon

Dental plaque, a biofilm that builds up on teeth

This is one culprit dancer:,

This is the Other Dancer:


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